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1

Spectroscopic studies on the TiCl4-promoted reaction of allylsilanes with aldehydes and α,β-enones

Scott E. Denmark, Neil G. Almstead

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.07 MB

english, 1992

2

Safety, Tolerability, and Pharmacokinetics of PTC124, a Nonaminoglycoside Nonsense Mutation Suppressor, Following Single- and Multiple-Dose Administration to Healthy Male and Female Adult Volunteers

Hirawat, Samit, Welch, Ellen M., Elfring, Gary L., Northcutt, Valerie J., Paushkin, Sergey, Hwang, Seongwoo, Leonard, Eileen M., Almstead, Neil G., Ju, William, Peltz, Stuart W., Miller, Langdon L.

Journal:

Journal of Clinical Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 337 KB

english, 2007

3

ChemInform Abstract: Oxazolidinone to Succinamide: A Novel Rearrangement Reaction.

Menyan Cheng, Biswanath De, Christopher T. Wahl, Neil G. Almstead, Michael G. Natchus, Stanislaw Pikul

Journal:

Année:

1999

Fichier:

PDF, 27 KB

1999

4

ChemInform Abstract: The Next Generation of MMP Inhibitors: Design and Synthesis

Biswanath De, Michael G. Natchus, Menyan Cheng, Stanislaw Pikul, Neil G. Almstead, Yetunde O. Taiwo, Catherine E. Snider, Longyin Chen, Bobby Barnett, Fei Gu, et al. et al.

Journal:

Année:

1999

Fichier:

PDF, 26 KB

1999

5

1,4-radical elimination in cyclohexene systems: A model for the chorismate synthase reaction

Bernd Giese, Neil G. Almstead

Journal:

Tetrahedron Letters

Année:

1994

Langue:

english

Fichier:

PDF, 302 KB

english, 1994

6

Oxazolidinone to succinamide: a novel rearrangement reaction

Menyan Cheng, Biswanath De, Christopher T. Wahl, Neil G. Almstead, Michael G. Natchus, Stanislaw Pikul

Journal:

Tetrahedron Letters

Année:

1999

Langue:

english

Fichier:

PDF, 155 KB

english, 1999

7

Gas chromatographic–mass spectrometric analysis of hydroxylamine for monitoring the metabolic hydrolysis of metalloprotease inhibitors in rat and human liver microsomes

Sean X. Peng, Michael J. Strojnowski, Joanna K. Hu, Bill J. Smith, Thomas H. Eichhold, Kenneth R. Wehmeyer, Stanislaw Pikul, Neil G. Almstead

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1999

Langue:

english

Fichier:

PDF, 136 KB

english, 1999

8

Heterocycle-based MMP Inhibitors with P2′ Substituents

Stanislaw Pikul, Kelly McDow Dunham, Neil G Almstead, Biswanath De, Michael G Natchus, Yetunde O Taiwo, Lisa E Williams, Barbara A Hynd, Lily C Hsieh, Michael J Janusz, Fei Gu, Glen E Mieling

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 346 KB

english, 2001

9

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

Joshua S. Tullis, Matthew J. Laufersweiler, John C. VanRens, Michael G. Natchus, Roger G. Bookland, Neil G. Almstead, Stanislaw Pikul, Biswanath De, Lily C. Hsieh, Michael J. Janusz, Todd M. Branch, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 160 KB

english, 2001

10

Design and synthesis of conformationally-constrained MMP inhibitors

Michael G. Natchus, Menyan Cheng, Christopher T. Wahl, Stanislaw Pikul, Neil G. Almstead, Rimma S. Bradley, Yetunde O. Taiwo, Glen E. Mieling, C.Michelle Dunaway, Catherine E. Snider, John M. McIver,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 272 KB

english, 1998

11

The Next Generation of MMP Inhibitors: Design and Synthesis

BISWANATH DE, MICHAEL G. NATCHUS, MENYAN CHENG, STANISLAW PIKUL, NEIL G. ALMSTEAD, YETUNDE O. TAIWO, CATHERINE E. SNIDER, LONGYIN CHEN, BOBBY BARNETT, FEI GU, MARTIN DOWTY

Journal:

Annals of the New York Academy of Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 711 KB

english, 1999

12

Studies on the mechanism and origin of stereoselective opening of chiral dioxane acetals

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of the American Chemical Society

Année:

1991

Langue:

english

Fichier:

PDF, 3.00 MB

english, 1991

13

Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors

Cheng, Menyan, De, Biswanath, Pikul, Stanislaw, Almstead, Neil G., Natchus, Michael G., Anastasio, Melanie V., McPhail, Sara J., Snider, Catherine E., Taiwo, Yetunde O., Chen, Longyin

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 531 KB

english, 2000

14

On the stereochemical course of the addition of allylsilanes to aldehydes

Scott E. Denmark, Eric J. Weber, Neil G. Almstead, Larry M. Wolf

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2012

15

Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines

Natchus, Michael G., Bookland, Roger G., Laufersweiler, Matthew J., Pikul, Staszek, Almstead, Neil G., De, Biswanath, Janusz, Michael J., Hsieh, Lily C., Gu, Fei, Pokross, Matthew E., Patel, Vikram S.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 326 KB

english, 2001

16

Selective Synthesis of 1-Substituted 4-Chloropyrazolo[3,4- d ]pyrimidines

Babu, Suresh, Morrill, Christie, Almstead, Neil G., Moon, Young-Choon

Journal:

Organic Letters

Année:

2013

Langue:

english

Fichier:

PDF, 181 KB

english, 2013

17

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Cheng, Menyan, De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Dowty, Martin E., Dietsch, Charles R., Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C., Janusz, Michael J., Taiwo, Yetunde O., Natchus,

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 282 KB

english, 1999

18

Spectroscopic studies on the structure and conformation of Lewis acid-aldehyde complexes

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of the American Chemical Society

Année:

1993

Langue:

english

Fichier:

PDF, 866 KB

english, 1993

19

Stereochemical Studies on the Addition of Allylsilanes to Aldehydes. The SE' Component

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of Organic Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 359 KB

english, 1994

20

Stereoselective opening of chiral dioxane acetals. Nucleophile dependence

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of Organic Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 398 KB

english, 1991

21

On the stereoselectivity opening of achiral dioxane acetals

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of Organic Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.74 MB

english, 1991

22

Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors

Pikul, Stanislaw, McDow Dunham, Kelly L., Almstead, Neil G., De, Biswanath, Natchus, Michael G., Anastasio, Melanie V., McPhail, Sara J., Snider, Catherine E., Taiwo, Yetunde O., Rydel, Timothy, Dunaw

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 127 KB

english, 1998

23

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Almstead, Neil G., Bradley, Rimma S., Pikul, Stanislaw, De, Biswanath, Natchus, Michael G., Taiwo, Yetunde O., Gu, Fei, Williams, Lisa E., Hynd, Barbara A., Janusz, Michael J., Dunaway, C. Michelle, M

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 507 KB

english, 1999

24

The Design and Synthesis of Sulfur Containing Bisphosphonic Acids for the Treatment of Arthritis

Almstead, Neil G., Dansereau, Susan M., Francis, Marion D., Snider, Catherine M., Ebetino, Frank H.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Année:

1999

Langue:

english

Fichier:

PDF, 203 KB

english, 1999

25

Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines

Natchus, Michael G., Bookland, Roger G., De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Janusz, Michael J., Heitmeyer, Sandra A., Hookfin, Erin B., Hsieh, Lily C., Dowty, Martin E., Dietsch, Char

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 398 KB

english, 2000

26

Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B

Zhang, Xiaoyan, Zhang, Nanjing, Chen, Guangming, Turpoff, Anthony, Ren, Hongyu, Takasugi, James, Morrill, Christie, Zhu, Jin, Li, Chunshi, Lennox, William, Paget, Steven, Liu, Yalei, Almstead, Neil, G

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 3.01 MB

english, 2013

27

Structure–Activity Relationship (SAR) Optimization of 6-(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B

Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil,

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 650 KB

english, 2014

28

Synthesis of 1,4-Disubstituted Pyrazolo[3,4-d]pyrimidines from 4,6-Dichloropyrimidine-5-carboxaldehyde: Insights into Selectivity and Reactivity

Morrill, Christie, Babu, Suresh, Almstead, Neil, Moon, Young-Choon

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 323 KB

english, 2013

29

Discovery of N-(4′-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication

Chen, Guangming, Ren, Hongyu, Turpoff, Anthony, Arefolov, Alexander, Wilde, Richard, Takasugi, James, Khan, Atiyya, Almstead, Neil, Gu, Zhengxian, Komatsu, Takashi, Freund, Connie, Breslin, Jamie, Col

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2013

30

Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Pikul, Stanislaw, Ohler, Norman E., Ciszewski, Greg, Laufersweiler, Michael C., Almstead, Neil G., De, Biswanath, Natchus, Michael G., Hsieh, Lily C., Janusz, Michael J., Peng, Sean X., Branch, Todd M

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 54 KB

english, 2001

31

Design and Synthesis of Phosphinamide-Based Hydroxamic Acids as Inhibitors of Matrix Metalloproteinases

Pikul, Stanislaw, McDow Dunham, Kelly L., Almstead, Neil G., De, Biswanath, Natchus, Michael G., Anastasio, Melanie V., McPhail, Sara J., Snider, Catherine E., Taiwo, Yetunde O., Chen, Longyin, Dunawa

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 141 KB

english, 1999

32

The origin of stereoselective opening of chiral dioxane and dioxolane acetals: solution structure of their Lewis acid complexes

Denmark, Scott E., Willson, Timothy M., Almstead, Neil G.

Journal:

Journal of the American Chemical Society

Année:

1989

Langue:

english

Fichier:

PDF, 407 KB

english, 1989

33

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B

Chen, Guangming, Ren, Hongyu, Zhang, Nanjing, Lennox, William, Turpoff, Anthony, Paget, Steven, Li, Chunshi, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Colacino

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 383 KB

english, 2015

34

ChemInform Abstract: Selective Synthesis of 1-Substituted 4-Chloropyrazolo[3,4-d]pyrimidines.

Babu, Suresh, Morrill, Christie, Almstead, Neil G., Moon, Young-Choon

Journal:

Année:

2013

Fichier:

PDF, 33 KB

2013

35

Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil, Moon, Young-Choon

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 383 KB

english, 2013

36

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B

Zhang, Nanjing, Turpoff, Anthony, Zhang, Xiaoyan, Huang, Song, Liu, Yalei, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Pichardo, John, Colacino, Joseph, Lahser,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 2.77 MB

english, 2015

37

ChemInform Abstract: Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines.

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil G., Moon, Young-Choon

Journal:

Année:

2013

Fichier:

PDF, 42 KB

2013

38

ChemInform Abstract: Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines.

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil G., Moon, Young-Choon

Journal:

Année:

2013

Fichier:

PDF, 36 KB

2013

39

ChemInform Abstract: Synthesis of 1,4-Disubstituted Pyrazolo[3,4-d]pyrimidines from 4,6-Dichloropyrimidine-5-carboxaldehyde: Insights into Selectivity and Reactivity.

Morrill, Christie, Babu, Suresh, Almstead, Neil G., Moon, Young-Choon

Journal:

Année:

2013

Fichier:

PDF, 36 KB

2013

40

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation

Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spie

Journal:

Clinical Pharmacology in Drug Development

Année:

2016

Langue:

english

Fichier:

PDF, 661 KB

english, 2016

41

4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis

Arnold, Michael A., Gerasyuto, Aleksey I., Wang, Jiashi, Du, Wu, Gorske, Yi Jin Kim, Arasu, Tamil, Baird, John, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Ginzburg, Olya, Lue, Stanley W.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 2.24 MB

english, 2017

42

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multi-Drug Resistant Gram-Negative Bacteria

Gerasyuto, Aleksey I, Arnold, Michael A, Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G., Baird, John, Zhang, Nanjing, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivas

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 933 KB

english, 2018

43

Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria

Gerasyuto, Aleksey I., Arnold, Michael A., Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G., Baird, John, Zhang, Nanjing, Almstead, Neil G., Narasimhan, Jana, Peddi, Sriniv

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 342 KB

english, 2018

44

Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects

Kong, Ronald, Laskin, Oscar L., Kaushik, Diksha, Jin, Fengbin, Ma, Jiyuan, McIntosh, Joseph, Souza, Marcio, Almstead, Neil

Journal:

Clinical Pharmacology in Drug Development

Année:

2019

Langue:

english

Fichier:

PDF, 285 KB

english, 2019

45

Metabolism and Disposition of Ataluren following Oral Administration to Mice, Rats, Dogs, and Humans

Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Goodwin, Elizabeth, Northcutt, Valerie, Babiak, John, Almstead, Neil, McIntosh, Joseph

Journal:

Drug Metabolism and Disposition

Année:

2020

Fichier:

PDF, 702 KB

2020

46

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, YoungâChoon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth

Journal:

Pharmacology Research & Perspectives

Année:

2020

Langue:

english

Fichier:

PDF, 2.58 MB

english, 2020